Conceptual Modeling in Systems Biology Fosters Empirical Findings: The mRNA Lifecycle
Dov Dori, Mordechai Choder · 2007
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Description
Dov Dori and Mordechai Choder argued that clear conceptual models can lead to real findings in systems biology, in PLOS ONE in 2007. Biology now produces facts far faster than any one person can hold in mind. Many modeling tools, they note, struggle to show both structure and behavior at the same time.
To make their case, the authors work through the life cycle of messenger RNA, the copy of a gene that cells use to build proteins. They show how a careful model of that cycle can point to things worth testing in the lab. The article is part method paper, part plea for better shared language.
Catalog record
| CREATOR | Dov Dori, Mordechai Choder |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000872