Discovery of Genes Activated by the Mitochondrial Unfolded Protein Response (mtUPR) and Cognate Promoter Elements
Jonathan E. Aldridge, Tomohisa Horibe, Nicholas J. Hoogenraad · 2007
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Description
Jonathan Aldridge, Tomohisa Horibe and Nicholas Hoogenraad hunted for genes switched on by the mitochondrial unfolded protein response, in PLOS ONE in 2007. Mitochondria are the cell's power plants. When their proteins fold badly, the cell answers with a stress program that turns certain genes on.
A companion study had shown the response starts through a gene called chop and a partner called C/EBP beta. Here the team looked for the wider set of genes that follow, and for the promoter elements, the DNA switches that control them. Mapping that set helps explain how cells cope when their power plants are under strain.
Catalog record
| CREATOR | Jonathan E. Aldridge, Tomohisa Horibe, Nicholas J. Hoogenraad |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000874