Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse
Rita A. Busuttil, Ana Maria Garcia, Robert L. Reddick et al. · 2007
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Description
Rita Busuttil, Ana Maria Garcia, Robert Reddick and co-authors tracked how mutations build up with age inside mouse organs, for PLOS ONE in 2007. Earlier work with a special test mouse had shown changes pile up far faster in the small intestine than in the brain. The open question was how uneven that pattern is within a single organ.
Using the same model, the team compared sites inside the small intestine. They report that point mutations, single letter changes in DNA, do not land evenly. Uneven damage may help explain why some tissues age faster and face higher cancer risk. The study treats aging as a local process, not a uniform one.
Catalog record
| CREATOR | Rita A. Busuttil, Ana Maria Garcia, Robert L. Reddick et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000876