An All-Atom Model of the Chromatin Fiber Containing Linker Histones Reveals a Versatile Structure Tuned by the Nucleosomal Repeat Length
Hua Wong, Jean-Marc Victor, Julien Mozziconacci · 2007
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Description
Hua Wong, Jean-Marc Victor and Julien Mozziconacci built an atom-by-atom model of the chromatin fiber, published in PLOS ONE in 2007. Inside the cell nucleus, histone proteins wrap DNA into a packed, ordered structure. That packing controls which genes can be read and when.
The team built their model from known structures: the nucleosome core, plain DNA and part of a linker histone called H5. Their fiber includes those linker histones, which many simpler models leave out. The result is a flexible structure whose shape shifts with the spacing between nucleosomes. Such models help turn static pictures of DNA packing into testable ideas.
Catalog record
| CREATOR | Hua Wong, Jean-Marc Victor, Julien Mozziconacci |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000877