Molecular and Structural Discrimination of Proline Racemase and Hydroxyproline-2-Epimerase from Nosocomial and Bacterial Pathogens
Maira Goytia, Nathalie Chamond, Alain Cosson et al. · 2007
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Description
Maira Goytia, Nathalie Chamond, Alain Cosson and co-authors compared two closely related enzymes from harmful germs, in PLOS ONE in 2007. One enzyme, proline racemase, comes from the parasite that causes Chagas disease. It is a confirmed drug target because the parasite needs it to live and spread in its host.
The puzzle is that a near twin enzyme, hydroxyproline epimerase, does a slightly different job. Mixing the two up could mislead drug design. The team set out the molecular and structural marks that separate them. Clear marks like these help chemists aim at the parasite enzyme without hitting the wrong target.
Catalog record
| CREATOR | Maira Goytia, Nathalie Chamond, Alain Cosson et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000885