The Restriction of Zoonotic PERV Transmission by Human APOBEC3G
Stefán R. Jónsson, Rebecca S. LaRue, Mark D. Stenglein et al. · 2007
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Description
Stefan Jonsson, Rebecca LaRue, Mark Stenglein and colleagues tested how a human protein blocks a pig retrovirus, in PLOS ONE in 2007. The protein, APOBEC3G, is part of the body's built-in defense against viruses. It can stop some retroviruses, including ones that live permanently in animal genomes.
The virus in focus, PERV, lives in pigs and is a concern for transplanting pig organs into people. Using long term cell cultures, the team asked whether APOBEC3G can restrict its spread between species. The work bears on xenotransplantation, using animal organs for human patients. Safety there depends on knowing which human defenses actually hold.
Catalog record
| CREATOR | Stefán R. Jónsson, Rebecca S. LaRue, Mark D. Stenglein et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000893