Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian-Specific Theta and Epsilon Subunits
Christopher J. Martyniuk, Stéphane Aris-Brosou, Guy Drouin et al. · 2007
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Description
Christopher Martyniuk, Stephane Aris-Brosou, Guy Drouin and co-authors traced the early history of GABA receptors, for PLOS ONE in 2007. GABA is a major calming signal chemical in the brain, in both backboned and spineless animals. Its receptors help run learning and memory, yet little was known about how fast or in what pattern they evolved.
The team focused on two receptor parts found only in mammals, called theta and epsilon. They asked what kind of selection shaped them over time. Tracing receptor history can explain why drugs that act on GABA vary across species. It also shows how a key brain system was assembled piece by piece.
Catalog record
| CREATOR | Christopher J. Martyniuk, Stéphane Aris-Brosou, Guy Drouin et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000894