DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons
Kimberly D. Siegmund, Caroline M. Connor, Mihaela Campan et al. · 2007
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Description
Kimberly Siegmund, Caroline Connor, Mihaela Campan and colleagues mapped DNA methylation in the human cortex across life, in PLOS ONE in 2007. Methylation is a chemical mark on DNA that helps control how genes are used. Its role in normal brain growth, aging and disease was still unclear.
Using a PCR based method, the team checked marks at fifty places in the genome, many near gene start sites. They report that marks in the cortex shift over the life span, and that mature nerve cells are part of that story. Changing marks may be one way the aging brain drifts from its younger state.
Catalog record
| CREATOR | Kimberly D. Siegmund, Caroline M. Connor, Mihaela Campan et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000895