Evidence Based Selection of Housekeeping Genes
Hendrik J. M. de Jonge, Rudolf S. N. Fehrmann, Eveline S. J. M. de Bont et al. · 2007
Read Evidence Based Selection of Housekeeping Genes by Hendrik J. M. de Jonge, Rudolf S. N. Fehrmann, Eveline S. J. M. de Bont et al. (2007) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0000898.txt.
Description
Hendrik de Jonge, Rudolf Fehrmann, Eveline de Bont and colleagues set out to choose housekeeping genes on evidence, in PLOS ONE in 2007. Gene studies need steady reference genes to make fair comparisons. The catch is that popular choices such as ACTB and GAPDH can swing widely between samples and conditions.
Unsteady references quietly corrupt results across whole fields. The team weighed candidates against data rather than habit, aiming for references that stay level. Their selection gives labs a safer base for measuring gene activity. The paper is a methods warning as much as a result: check your ruler before you measure.
Catalog record
| CREATOR | Hendrik J. M. de Jonge, Rudolf S. N. Fehrmann, Eveline S. J. M. de Bont et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000898