Basonuclin Regulates a Subset of Ribosomal RNA Genes in HaCaT Cells
Shengliang Zhang, Junwen Wang, Hung Tseng · 2007
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Description
Shengliang Zhang, Junwen Wang and Hung Tseng studied a protein that switches on a subset of ribosomal RNA genes, in PLOS ONE in 2007. The protein, basonuclin, is found mainly in skin type cells and in egg and sperm forming cells. Ribosomal RNA genes make the core parts of ribosomes, the cell's protein building machines.
Earlier lab work showed basonuclin binds the start region of these genes at three strong sites. Using HaCaT skin cells, the team asked which gene copies it actually regulates in living cells. The answer helps explain how cells tune protein production to match growth. It also clarifies a specialist protein with a narrow but key job.
Catalog record
| CREATOR | Shengliang Zhang, Junwen Wang, Hung Tseng |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000902