Comparative Genomics of Bordetella pertussis Reveals Progressive Gene Loss in Finnish Strains
Eriikka Heikkinen, Teemu Kallonen, Lilli Saarinen et al. · 2007
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Description
Eriikka Heikkinen, Teemu Kallonen, Lilli Saarinen and colleagues compared whooping cough germs across Finland, in PLOS ONE in 2007. Bordetella pertussis causes whooping cough and has returned in many countries. Finland has used the whole cell vaccine for more than fifty years, yet cases rose again.
The team compared genomes of Finnish strains and report steady gene loss over time. A germ that sheds genes while a vaccine presses on it raises hard questions about adaptation. Their comparison helps health officials judge whether vaccines still match the germ in circulation. It also shows evolution at work inside a single country.
Catalog record
| CREATOR | Eriikka Heikkinen, Teemu Kallonen, Lilli Saarinen et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000904