Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype
Nicola K. Viebig, Emily Levin, Sébastien Dechavanne et al. · 2007
Read Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype by Nicola K. Viebig, Emily Levin, Sébastien Dechavanne et al. (2007) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0000910.txt.
Description
Nicola Viebig, Emily Levin, Sebastien Dechavanne and colleagues disabled a malaria gene and watched what changed, in PLOS ONE in 2007. Malaria in pregnancy is a major cause of illness and death for mothers and newborns. Much of the harm comes from infected red blood cells sticking in the placenta in huge numbers.
The sticking depends on a parasite gene called var2csa. The team disrupted that gene and report that the placental adhesion trait was impaired. A result like this matters for vaccine hopes: a protein needed for sticking is a natural target. It also confirms, by removal, what var2csa actually does.
Catalog record
| CREATOR | Nicola K. Viebig, Emily Levin, Sébastien Dechavanne et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000910