Connector Inversion Probe Technology: A Powerful One-Primer Multiplex DNA Amplification System for Numerous Scientific Applications
Michael S. Akhras, Magnus Unemo, Sreedevi Thiyagarajan et al. · 2007
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Description
Michael Akhras, Magnus Unemo, Sreedevi Thiyagarajan and colleagues built a one primer system that copies many DNA targets at once, in PLOS ONE in 2007. Their method grows out of an older assay called the molecular inversion probe. The team added a complete gap filling step to make it stronger.
They call the result connector inversion probe technology. As a proof of concept, they show it can amplify many chosen sequences in a single reaction. Copying many targets at once, cleanly, is the backbone of genetic testing and pathogen hunting. A flexible system like this can serve labs that need wide screens from small samples.
Catalog record
| CREATOR | Michael S. Akhras, Magnus Unemo, Sreedevi Thiyagarajan et al. |
|---|---|
| YEAR | 2007 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000915